A Rehabilomics Framework for Personalized and Translational Rehabilitation Research and Care for Individuals with Disabilities: Perspectives and Parallels for Spinal Cord Injury

Short Title:
A Rehabilomics Framework for Personalized and Translational Rehabilitation Research and Care for Individuals with Disabilities: Perspectives and Parallels for Spinal Cord Injury
Model System:
Burn
Reference Type:
Journal Article
Accession No.:
J69850
Journal:
JOURNAL OF SPINAL CORD MEDICINE
Year, Volume, Issue, Page(s):
2015, vol. 1, issue 37, pp 493-502
Publication Website:
Abstract:
Article introduces the Rehabilomics framework, a translational model that provides an “-omics” overlay to the scientific study of rehabilitation processes and multidimensional outcomes. Despite many people having similar clinical presentation, demographic factors, and clinical care, outcome can differ for those sustaining significant injury such as spinal cord injury (SCI) and traumatic brain injury. This variability may be attributable to innate (including genetic, transcriptomic proteomic, epigenetic) biological variation that individuals bring to recovery and their unique response to their care and environment. Technologies collectively called “-omics” enable simultaneous measurement of an enormous number of biomolecules that can capture many potential biological contributors to heterogeneity of injury/disease course and outcome. Due to the nature of injury and complex disease, and its associations with impairment, disability, and recovery, rehabilitation does not lend itself to a singular “protocolized” plan of therapy. Yet, by nature and by necessity, rehabilitation medicine operates as a functional model of personalized care. Rehabilomics research provides novel opportunities to evaluate the neurobiology of complex injury or chronic disease and can be used to examine methods and treatments for person-centered care among populations with disabilities. Examples for application in SCI and other neurorehabilitation populations are discussed.
Author(s):
Levi B, Jayakumar P, Goldstein R, Jupiter J, Ring DC, Giladi A, Kowalske K, Amtmann D, Schneider JC, Ryan CM.
Author Address(es):

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