Longitudinal White Matter Changes after Traumatic Axonal Injury

Short Title:
Longitudinal White Matter Changes after Traumatic Axonal Injury
Model System:
Reference Type:
Journal Article
Accession No.:
Journal of Neurotrauma
Year, Volume, Issue, Page(s):
2014, vol. 1, issue , pp PubMed PMID 24738754
Publication Website:
Study examined changes in white matter (WM) integrity following after traumatic axonal injury (TAI) using diffusion tensor imaging (DTI). Sixteen patients with complicated mild to severe brain injuries consistent with TAI were recruited in the intensive care unit of a Level I trauma center. Thirteen of these patients were studied longitudinally over the course of the first seven months post-injury. The first scan occurred, on average, 1 day after injury and the second an average of seven months post-injury. Ten healthy individuals, similar to the cohort of patients, were recruited as controls. Whole brain WM and voxel-based analyses of DTI data were conducted. DTI metrics of interest included: fractional anisotropy (FA), mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD). Tract-based spatial statistics were used to examine DTI metrics spatially. Acutely, AD and RD increased and RD positively correlated with injury severity. Longitudinal analysis showed reduction in FA and AD, but no change in RD. Possible explanations for the microstructural changes observed over time are discussed.
Perez AM, Adler J, Kulkarni N, Strain JF, Womack KB, Diaz-Arrastia R, Marquez de la Plata CD
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