Acute inflammatory biomarker profiles predict depression risk following moderate to severe traumatic brain injury

Short Title:
Acute inflammatory biomarker profiles predict depression risk following moderate to severe traumatic brain injury
Model System:
TBI
Reference Type:
Journal Article
Accession No.:
J71790
Journal:
Journal of Head Trauma Rehabilitation
Year, Volume, Issue, Page(s):
2014, vol. 1, issue , pp Epub
Publication Website:
Abstract:
Study investigated whether acute in?ammation pro?les predict posttraumatic depression (PTD) risk 6 and 12 months after moderate-to-severe traumatic brain injury (TBI). A total of 41 participants had acute cerebrospinal ?uid (CSF) inflammatory biomarker values, and 50 participants had acute serum inflammatory biomarker values. Outcome variables included the Patient Health Questionnaire and in?ammatory biomarkers: interleukin (IL)-1ß, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, tumor necrosis factor a, soluble vascular adhesion molecule (sVCAM-1), soluble intracellular adhesion molecule (sICAM-1), and soluble Fas (sFAS). Higher levels of acute CSF cytokine surface markers (sVCAM-1, sICAM-1, and sFAS) in an in?ammatory biomarker risk (IBR) score were associated with a 3.920-fold increase in the odds of developing PTD at 6 months. Having sICAM-1, sVCAM-1, or sFAS above the 75th percentile had a positive predictive value of 85.7 percent for PTD risk at 6 months. An IBR score including in?ammatory biomarkers IL-7 and IL-8 showed a trending association with 12-month PTD risk. Acute CSF IBR scores show promise for identifying individuals with TBI at risk for PTD. Further research should assess acute CSF in?ammatory biomarkers’ relationships to chronic in?ammation as a mechanism of PTD and should explore anti-in?ammatory treatments for PTD, as well as prevention and screening protocols, and link in?ammatory biomarkers to symptom tracking.
Author(s):
Juengst, S.B., Kumar, R.G., Failla, M.D., Goyal, A., Wagner, A.K.
Author Address(es):
Participating Centers:

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