Diffusion tensor imaging biomarkers for traumatic axonal injury: Analysis of three analytic methods

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Journal Article
Accession No.:
Journal of the International Neuropsychological Society
Year, Volume, Issue, Page(s):
2011, vol. 17, issue 1, pp 24-35
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Study examined the utility of three methods that measure the degree of white matter (WM) injury following traumatic axonal injury (TAI) and their respective associations with functional and neurocognitive outcome. Diffusion tensor imaging (DTI) can detect microstructural compromise in WM in various clinical populations including TAI. DTI-derived data can be analyzed using global methods (WM histogram or voxel based approaches) or a regional approach (tractography). DTI images were obtained from 30 patients with TAI and 19 demographically similar normal controls. Patients were scanned approximately eight months post-injury, and underwent functional and neuropsychological outcomes assessments at that time. Histogram analysis of fractional anisotropy (FA) and mean diffusivity showed global WM integrity differences between patients and controls. Voxel-based and tractography analyses showed significant decreases in FA within centroaxial structures involved in TAI. All three techniques were associated with functional and cognitive outcomes. DTI measures of microstructural integrity appear robust, as the three analysis techniques studied showed adequate utility for detecting WM injury.
Marquez de la Plata C, Yang FG, Wang JY, Krishnan K, Bakhadirov K, Paliotta C, Aslan S, Devous MD, Moore C, Harper C, McColl R, Cullum CM, Diaz-Arrastia R
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