Functional genomics unique to week 20 post wounding in the deep cone/fat dome of the Duroc/Yorkshire porcine model of fibroproliferative scarring

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Journal Article
Accession No.:
PLoS One
Year, Volume, Issue, Page(s):
2011, vol. 6, issue 4, pp
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Study reports the differential transcriptome over time and the functional genomics unique to Week 20 post wounding from the deep cones/fat domes in the Duroc/Yorkshire porcine model of fibroproliferative scarring following shallow and deep partial thickness wounds. A system was assembled that permits the study of genome-wide gene expression in microanatomical locations, in shallow and deep partial-thickness wounds, and pigmented and non-pigmented skin, using the Duroc (pigmented fibroproliferative) and Yorkshire (non-pigmented non-fibroproliferative) porcine model. This system was used to obtain the differential transcriptome at 1, 2, 3, 12 and 20 weeks post wounding. It is not clear when fibroproliferation begins, but it is fully developed in humans and the Duroc breed at 20 weeks. Therefore, the authors obtained the derivative functional genomics unique to 20 weeks post wounding and also obtained long-term, forty-six week follow-up with the model. The differential transcriptome provided new insights into the fibroproliferative process as several genes thought fundamental to fibroproliferation were absent and others differentially expressed were newly implicated. The observation that the scars are still thick at forty-six weeks post wounding further validated the model.
Engrav LH, Tuggle CK, Kerr KF, Zhu KQ, Numhom S, Couture OP, Beyer RP, Hocking AM, Carrougher GJ, Ramos MLC, Klein MB, Gibran NS
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