Whole body protein kinetics measured with a non-invasive method in severely burned children

Short Title:
Model System:
Burn
Reference Type:
Journal Article
Accession No.:
J62895
Journal:
Burns
Year, Volume, Issue, Page(s):
2010, vol. 36, issue 7, pp 1006-1012
Publication Website:
Abstract:
Study measured whole body protein turnover in burned children at discharge (95 percent healed) and in healthy controls by a noninvasive stable isotope method. Nine burned children and 12 healthy children were studied. A single oral dose of an amino acid was given and thereafter urine was collected for 34 hours. Whole body protein flux was calculated from labeling of urinary urea nitrogen; protein synthesis was calculated as protein flux minus excretion, and protein breakdown as flux minus intake. At discharge, total protein turnover was 4.53 grams per kilogram per day in the burned children compared to 3.20 in controls. Total protein synthesis was also elevated in burned vs. healthy children, and a tendency for elevated protein breakdown was observed. Results indicate that total protein turnover is elevated in burned children at discharge compared to age-matched controls, possibly reflecting the continued stress response to severe burn. The oral amino acid bolus method is a convenient, non-invasive, and no-risk method for measurement of total body protein turnover.
Author(s):
Borsheim E, Chinkes DL, McEntire SJ, Rodriguez NR, Herndon DN, Suman OE
Author Address(es):

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