Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns

Short Title:
Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns
Model System:
Burn
Reference Type:
Journal Article
Accession No.:
J30816.
Journal:
Journal of Burn Care & Rehabilitation
Year, Volume, Issue, Page(s):
1996, vol. 17, issue 2, pp 124-136
Publication Website:
Abstract:
Clinical study examines the AlloDerm process that functions as a permanent dermal full-thickness autograft transplant that could reduce donor site trauma and complications. Current treatment is transplantation of split-thickness autografts that close the wound but create another at the donor site. The development of biosynthetic dermal substitutes is based on the mesh degrading in the wound healing process leaving behind fibroblasts and dermal proteins. The AlloDerm process removes the cells of both the epidermis and dermis and avoiding a specific immune response. The results of the AlloDerm processed matrix did not cause an inflammatory response. The migration and attachment of keratinocytes was supported by the meshed autograft. The study demonstrated that the success rate of the dermal matrix grafts and applied autografts were dependent on following a prescribed dressing protocol. Acceptance was highest when proper hydration of the grafted wound was maintained for 5 to 7 days after surgery. Perioperative care was critical to successful outcome. Another observation was that the higher take rates of thinner autografts applied over the dermal matrix promoted faster healing, less depigmentation and reduced scaring.
Author(s):
Wainwright, D.; Madden, M.; Luterman, A.; Hunt, J.; Monafo, W.; Heimbach, D.; Kagan, R.; Sittig, K.; Dimick, A.; Herndon, D.
Author Address(es):

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