Comparison of clinical and neurophysiologic responses to intrathecal baclofen bolus administration in moderate-to-severe spasticity after acquired brain injury

Short Title:
Comparison of clinical and neurophysiologic responses to intrathecal baclofen bolus administration in moderate-to-severe spasticity after acquired brain injury
Model System:
TBI
Reference Type:
Journal Article
Accession No.:
J49403.
Journal:
Archives of Physical Medicine and Rehabilitation
Year, Volume, Issue, Page(s):
2005, vol. 86, issue 9, pp 1801-1806
Publication Website:
Abstract:
Study evaluated clinical and neurophysiological responses to intrathecal baclofen bolus (ITB) injection in patients with spasticity resulting from acquired brain injury. Clinical evaluation of muscle hypertonia was performed using the Ashworth Scale the day before ITB bolus injection and at 2, 4, and 6 hours after the bolus. Neurophysiological evaluation included bilateral recordings of the H-reflex from the soleus muscle and F waves from the abductor hallucis in a supine position, before and immediately after the clinical evaluation. Peak-to-peak amplitudes of the maximal H-reflex and maximal M-wave amplitude were measured to determine the H/M ratio. Similarly, a mean F/M ratio was calculated for each subject by dividing the amplitude of each F wave into the maximal M-wave amplitude. Analyses showed that ITB bolus injection decreased both clinical and neurophysiologic measures of spasticity. Soleus H/M ratio was the most sensitive measure of physiological drug action. No correlation was found between the assessed clinical and neurophysiological measures, before or after the ITB bolus injection.
Author(s):
Stokic, Dobrivoje S.; Yablon, Stuart A.; Hayes, Antonio
Author Address(es):
Participating Centers:

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