Model System:

Burn

Reference Type:

Journal

Accession No.:

J73528

Journal:


Annals of Surgery

Year, Volume, Issue, Page(s):

, 259, 2, 381-387

Publication Website:

Abstract:

Study examined the incidence of single- or multiple-organ failure and its resultant clinical outcomes during acute hospitalization in pediatric burn patients. Patient outcomes are inherently dependent on intact organ function; however, burn injury affects the structure and function of almost every organ, but especially lung, liver, kidney, and heart. Therefore, single-organ failure and/or multiple-organ failure (MOF) are thought to contribute significantly to post-burn morbidity and mortality. The incidence of MOF was monitored in 821 pediatric burn patients during acute hospitalization. Patients were divided into groups based on of the incidence of single-organ-specific failure, MOF, and non-MOF. The DEN-VER2 score was used to assess organ-specific scores for lung, liver, kidney, and heart. The patient’s demographics, injury characteristics, and outcome parameters were recorded. Results indicate that respiratory failure has the highest incidence in the early phase of post-burn injury and decreases starting 5 days after burn injury. Cardiac failure was noted to have the highest incidence throughout hospital stay. Incidence of hepatic failure increases with the hospital length of stay and is associated with a high mortality during the late phase of the acute hospital stay. Renal failure has an unexpectedly low incidence but is associated with a high mortality during the first 3 weeks after burn injury. Three or more organ failure is associated with very high mortality. The findings of this study confirm the expected chronologic incidence of organ-specific failure and yield the long-term mortality from liver and renal failure.

Author(s):


Kraft, Robert, Herndon, David N., Finnerty, Celeste C., Shahrokhi, Shahriar, Jeschke, Marc G.

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