Model System:

Burn

Reference Type:

Journal

Accession No.:

J69028

Journal:


Medicine and Science in Sports and Exercise

Year, Volume, Issue, Page(s):

, , ,

Publication Website:

Abstract:

Study examined the effects of early outpatient exercise on muscle mass, function, and fractional synthetic rate in severely burned children. Forty-seven children with burns covering at least 40 percent of their total body surface area performed 12-weeks standard of care rehabilitation (SOC) or rehabilitative exercise training (RET) immediately following hospital discharge. Dual-energy X-ray absorptiometry was used to assess lean body mass (LBM) at discharge, post-treatment, and 12 months post-burn. Muscle function was evaluated with a Biodex Isokinetic Dynamometer and peak aerobic fitness (VO2peak) was measured using a modified Bruce treadmill protocol post-treatment. Stable isotope infusion studies were performed in a subset of patients (13 SOC and 11 RET) at discharge and post-treatment to determine mixed-muscle fractional synthetic rate. Relative peak torque and VO2peak was greater post-treatment with RET compared to SOC. In addition, RET increased whole-body and leg LBM compared to SOC. Furthermore, the percentage change in whole-body and leg LBM from discharge to 12 months post-burn was greater with RET compared to SOC. Muscle fractional synthetic rate decreased from discharge to post-treatment in both groups; however no differences were observed between treatment groups at each time-point. The results of this study suggest that early outpatient exercise training implemented at hospital discharge represents an effective intervention to improve muscle mass and function following severe burn injury.

Author(s):


Hardee, Justin P., Porter, Craig, Sidossis, Labros S., Borsheim, Elisabet, Carson, James A., Herndon, David N., Suman, Oscar E.

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