Model System:

Burn

Reference Type:

JA

Accession No.:

Journal:


Critical Care

Year, Volume, Issue, Page(s):

, 11, 4, R90

Publication Website:

Abstract:

BACKGROUND: Increased burn size leads to increased mortality of burned patients. Whether mortality is due to inflammation, hypermetabolism or other pathophysiologic contributing factors is not entirely determined. The purpose of the present study was to determine in a large prospective clinical trial whether different burn sizes are associated with differences in inflammation, body composition, protein synthesis, or organ function. METHODS: Pediatric burned patients were divided into four burn size groups: 80% TBSA burn. Demographic and clinical data, hypermetabolism, the inflammatory response, body composition, the muscle protein net balance, serum and urine hormones and proteins, and cardiac function and changes in liver size were determined. RESULTS: One hundred and eighty-nine pediatric patients of similar age and gender distribution were included in the study (80% TBSA burn, n = 21). Patients with larger burns had more operations, a greater incidence of infections and sepsis, and higher mortality rates compared with the other groups (P 80% TBSA group, followed by the 60-79% TBSA burn group (P 80% burns lost the most body weight, lean body mass, muscle protein and bone mineral content (P

Author(s):


Jeschke, M., Mlcak, R., Finnerty, C., Norbury, W., Gauglitz, G., Kulp, G., Herndon, D.

Participating Centers: