Adiponectin is a candidate biomarker of lower extremity bone density in men with chronic spinal cord injury

Short Title:
Adiponectin is a candidate biomarker of lower extremity bone density in men with chronic spinal cord injury
Model System:
SCI
Reference Type:
Journal Article
Accession No.:
J70834
Journal:
JOURNAL OF BONE AND MINERAL RESEARCH
Year, Volume, Issue, Page(s):
2014, vol. 1, issue 1, pp 251-259
Publication Website:
Abstract:
Study determined the association among bone mineral density (BMD), walking status, and circulating adipokines (adiponectin and leptin) in men with chronic spinal cord injury (SCI). In the general population, greater body fat is associated with greater BMD and this is often attributed to mechanical loading of the skeleton by fat mass and modulation of bone turn over by adipokines. A total of 149 participants were studied; 54 subjects walked independently or with an assistive device and 95 subjects used a wheelchair. Although adipokine levels did not vary significantly based on walking status, there was a significant inverse relationship between adiponectin and BMD in wheelchair users independent of body composition. The study found no association between adiponectin and BMD in the walkers and no association between leptin and BMD in either group. These findings suggest that for people with chronic SCI, walking may mitigate the effect of adiponectin-mediated bone loss. For wheelchair users, adipose-derived adiponectin may contribute to SCI-induced osteoporosis because the osteoprotective benefits of obesity appear to require mechanical loading during ambulation.
Author(s):
Doherty A, Battaglino R, Donovan J, Gagnon D, Lazzari A, Garshick E, Zafonte R, Morse LR
Author Address(es):
Participating Centers:

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