Differences in quality of life outcomes among depressed spinal cord injury trial participants

Short Title:
Differences in quality of life outcomes among depressed spinal cord injury trial participants
Model System:
Reference Type:
Journal Article
Accession No.:
Archives of Physical Medicine and Rehabilitation
Year, Volume, Issue, Page(s):
2015, vol. 1, issue 96, pp 340-348
Publication Website:
Study examined differences in quality of life (QOL) outcomes among individuals with spinal cord injury (SCI) who previously participated in a randomized controlled trial (RCT) of an antidepressant to treat major depressive disorder (MDD). Of the 133 subjects who were participated in the Project to Improve Symptoms and Mood after Spinal Cord Injury RCT, 124 participated in this study. QOL was assessed at baseline and 12-week follow-up using the Satisfaction with Life Scale and the physical and mental component summary scores of the Medical Outcomes Study 12-Item Short-Form Health Survey. Multivariable analyses were conducted, controlling for demographic, neurologic, and participatory factors and perceived functional limitations. Results indicated that a reduction in depressive symptoms over the course of a 12-week trial was predictive of increased QOL, which was measured as life satisfaction and mental well-being, within the context of other explanatory factors. However, reduction in symptoms did not explain differences in physical well-being among those with MDD. Perceived functional disability explained all 3 indices of QOL. The findings support the association of QOL to the reduction of depression symptoms among trial participants. This association differs depending on how QOL is defined and measured, with stronger relations observed with life satisfaction and mental well-being among those diagnosed with MDD. The lack of association between depression and physical well-being may be explained by participants’ subjective interpretation of physical well-being after SCI and their expectations and perceptions of improved physical health-related QOL based on the use of assistive technology.
Charlifue S
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