Outcome measures in spinal cord injury: recent assessments and recommendations for future directions
Year, Volume, Issue, Page(s):
2009, vol. 47, issue , pp 582-591
Study design: Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broadbased international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations. Objectives: Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies.Methods: a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI. Results: Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention. Conclusion: Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial. Spinal Cord (2009) 47, 582–591; doi:10.1038/sc.2009.18; published online 21 April 2009
Alexander M.,Anderson K.,Biering-Sorensen F.,Blight A.,Brannon R.,Bryce G.,Creasey A.,Catz A.,Curt A.,Donovan W.,Ditunno J.,Ellaway P.,Finnerup N.,Graves D.,Haynes B.,Heinemann A.,Jackson A.,Johnston M.,Kalpakjian C.,Kleitman N.,Krassioukov A.,Krogh K,Lam
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