Haptoglobin phenotype and apolopoprotein E. polymorphism: Relationship to posttraumatic seizures and neuropyschological functioning after traumatic brain injury

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Journal Article
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2009, vol. 16, issue 3, pp 501-506
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. Introduction2. Methods3. Results4. DiscussionReferencesAbstractThe relationship between genetic predisposition to reduced iron capacity and apolipoprotein E (APOE) with post-traumatic seizures (PTS) and neuropsychological outcomes was investigated in patients with traumatic brain injuries (TBI) from a prior valproate clinical study. Haptoglobin (Hp) concentration/phenotype and APOE genotype was determined in 25 PTS and 26 controls (no PTS) subjects ~10 year after TBI. Hp phenotype was also determined in previously collected frozen samples for 25 additional PTS and 32 no PTS subjects. There was no relationship between Hp phenotype or APOE genotype and occurrence of PTS. APOE genotype was not related to neuropsychological outcome; however when adjustments were made for differences in educational levels, APOE e4 subjects did worse especially on verbal intellectual and verbal memory skills. In contrast to our hypothesis, those with Hp 1-1 (high affinity binder of hemoglobin), scored somewhat worse on verbal IQ and Tapping D at 1 and 12 month after injury.
Anderson G.D. ,Temkin N.R., Dikmen S.S., Diaz-Arrastia R., Machamer J.E., Farhrenbruch C., Miller J.W., Sadrzadeh S.M.H.
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