Intensive insulin treatment increases donor site wound protein synthesis in burn patients

Short Title:
Model System:
Burn
Reference Type:
Journal Article
Accession No.:
J62901
Journal:
Surgery
Year, Volume, Issue, Page(s):
2011, vol. 149, issue 4, pp 512-518
Publication Website:
Abstract:
Study investigated whether intensive insulin treatment increases fractional synthesis rate (FSR) of the donor site wound protein and decreases the length of hospitalization normalized for total body surface area burned (LOS/TBSA). FSR of the donor site wound protein was measured in pediatric patients randomized to receive standard of care (control) or intensive insulin treatments. Depending on the postoperative day when the tracer study was done, studies were divided into early (less than 5 days) and late (5 or more days) periods. Data from 13 control group and 10 insulin group patients are presented. FSR of the donor site wound protein was greater in the insulin group at the early period of wound healing (control versus insulin, 8.2 versus 13.1 percent per day); but not at the late (control versus insulin, 19.7 versus 16.6 percent per day). Despite these differences, LOS/TBSA was not decreased in the insulin group. Correlation analyses demonstrated that, independent of the treatment regimen, FSR positively correlated with time after creation of the donor site and negatively correlated with LOS/TBSA.
Author(s):
Tuvdendorj D, Zhang XJ, Chinkes DL, Aarsland A, Kulp GA, Jeschke MG, Herndon DN
Author Address(es):

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