Changes in cardiac physiology after severe burn injury

Short Title:
Model System:
Burn
Reference Type:
Journal Article
Accession No.:
J60671
Journal:
Journal of Burn Care and Research
Year, Volume, Issue, Page(s):
2011, vol. 32, issue 2, pp 269-274
Publication Website:
Abstract:
Study investigated the extent and duration of cardiac stress after a severe burn. One hundred ninety-four patients with severe thermal injury, defined as 40 percent or greater total body surface area burned, were included in this study. Heart rate, mean arterial pressure, cardiac output (CO), stroke volume, cardiac index, and ejection fractions were measured at regular intervals from admission up to 2 years after injury. Rate pressure product was calculated as a correlate of myocardial oxygen consumption. All values were compared with normal nonburned children to validate the findings. Statistical analysis was performed using log transformed analysis of variance with Bonferroni correction and Student's t-test, where applicable. Heart rate, CO, cardiac index, and rate pressure product remained significantly increased in burned children for up to 2 years when compared with normal ranges, indicating vastly increased cardiac stress. Ejection fraction was within normal limits for 2 years. This study indicates that cardiac stress persists for at least 2 years after burn injury, and the authors suggest that attenuation of these detrimental responses may improve long-term morbidity.
Author(s):
Williams FN, Herndon DN, Suman OE, Lee JO, Norbury WB, Branski LK, Mlcak RP, Jeschke MG
Author Address(es):

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