Donor site wound protein synthesis correlates with length of acute hospitalization in severely burned children

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Reference Type:
Journal Article
Accession No.:
Wound Repair and Regeneration
Year, Volume, Issue, Page(s):
2010, vol. 18, issue 3, pp 277-283
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Study examined donor site wound protein fractional synthesis rate (FSR) in pediatric burn patients and investigated how the protein synthesis relates to the total body surface area burns (TBSA) and overall length of stay (LOS) in the hospital. Autografting of burn wounds results in generation of donor site wounds. Eleven patients participated in a metabolic study consisting of continuous stable isotope infusion and donor site wound punch biopsies an average of 3.9 days after the grafting surgery. Donor site wound protein FSR was 10.4 percent per day. Wound FSR demonstrated linear correlation with the time postsurgery. Multiple regression analysis showed that LOS/TBSA correlated with donor site wound protein FSR and time postsurgery and the following equation describes the relationship: estimated LOS/TBSA = (FSR - 12.95 - 1.414 × postsurgery day)/(-17.8). This equation predicted that FSR corrected for the postsurgery day when the metabolic study was conducted accounted for 67 percent of the variability in the LOS/TBSA. Measurement of protein deposition in regenerating donor site wound using stable isotope technique provides a quantitative measure of wound healing. These results show that FSR increases over time postsurgery and correlates with LOS normalized for TBSA burn size.
Demidmaa, T.; Chinkes, D.L.; Zhang, X.; Aarsland, A.; Herndon, D.N.
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