Body composition changes with time in pediatric burn patients

Short Title:
Body composition changes with time in pediatric burn patients
Model System:
Burn
Reference Type:
Journal Article
Accession No.:
Journal:
J. Trauma
Year, Volume, Issue, Page(s):
2006, vol. 60, issue 5, pp 968-971
Publication Website:
Abstract:
Background: Major trauma and burns are associated with whole body catabolism which can persist for 1 or more years after injury. This study investigates body composition in massively burned children for up to 2 years. Methods: Twenty-five pediatric patients with greater than 40% total body surface area burns were studied. At discharge, 6, 12, 18, and 24 months after burn height, weight, body composition, resting energy expenditure (REE), serum growth hormone, insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), insulin, cortisol, parathyroid hormone, and thyroid hormones were measured. Tukey's test was used for analysis. Significance was accepted at p < 0.05. Results: Lean body mass, fat mass, bone mineral content, height, and weight increased significantly during the second year after burn. Percent predicted REE decreased significantly, whereas IGFBP-3 and parathyroid hormone levels increased significantly over time. Insulin and T3 uptake were significantly higher at discharge. Conclusions: Body composition of severely burned children significantly improved in the second year compared with the first year after injury. This demonstrates a need for long-term rehabilitation in these burn patients.
Author(s):
Przkora, R.; Barrow, R.E.; Jeschke, M.G.; Suman, O.E.; Celis, M.; Sanford, A.P.; Chinkes, D.L.; Mlcak, R.P.; Herndon, D.N.
Author Address(es):

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