Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury

Short Title:
Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury
Model System:
TBI
Reference Type:
Journal Article
Accession No.:
Journal:
Brain Injury
Year, Volume, Issue, Page(s):
2008, vol. 22, issue 7-8, pp 6112-615
Publication Website:
Abstract:
PRIMARY OBJECTIVE: To determine if plasma levels of 24S-hydroxycholesterol, the primary catabolite of brain cholesterol, provide a measure of axonal damage in acute brain trauma. RESEARCH DESIGN: Determination of plasma 24S-hydroxycholesterol in a series of persons admitted to an intensive care unit for treatment of closed head injury. METHODS AND PROCEDURES: Levels of 24-S-hydroxycholesterol, 27-hydroxycholesterol, lathosterol and total cholesterol were measured in peripheral blood from 38 persons from 14-55 years of age treated by craniotomy and ventriculostomy for intractable intracerebral hypertension. Severity of brain injury was estimated by the Glasgow Coma Scale (range = 3-13, median = 6 points) and overall injury by the Injury Severity Scale (range = 10-48, median = 29). All subjects were intubated and anaesthetized with intravenous propofol. Plasma sterol levels were compared with those of age-matched control subjects. OUTCOMES AND RESULTS: There was no significant increase in plasma 24-S-hydroxycholesterol in subjects with head injury, but measures of peripheral cholesterol synthesis were markedly reduced as compared with values for age-matched normal control subjects. CONCLUSION: Plasma 24S-hydroxycholesterol levels do not change with severe closed head injury.
Author(s):
Weiner, M. F.; Vega, G. L.; Diaz-Arrastia, R.; Moore, C.; Madden, C.; Hudak, A.; Lutjohann, D.
Author Address(es):
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA

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