Effect of exogenous growth hormone and exercise on lean mass and muscle function in children with burns

Short Title:
Effect of exogenous growth hormone and exercise on lean mass and muscle function in children with burns
Model System:
Burn
Reference Type:
Journal Article
Accession No.:
J48256.
Journal:
Journal of Applied Physiology
Year, Volume, Issue, Page(s):
2003, vol. 94, issue 6, pp 2273-2281
Publication Website:
Abstract:
Article reports that long-term administration of low doses of exogenous recombinant human growth hormone to children with severe burn injury improved lean body mass and bone mineral content compared to control subjects. However, only children participating in a 12-week exercise program also significantly improved muscle strength. Combining growth hormone and the exercise program appears to significantly increase lean body mass, but not to a significantly greater extent than growth hormone alone or exercise alone. No deleterious side effects of growth hormone were observed. This document is included in NCDDR's Guide to Resources Produced by National Institute on Disability and Rehabilitation Research (NIDRR) Grantees: Infants, Children, and Youth with Disabilities, number B.6.
Author(s):
Suman, Oscar E.; Thomas, Steve J.; Wilkins, Judy P.; Mlcak, Ronald P.; Herndon, David N.
Author Address(es):

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