Differential cerebellar activation on functional magnetic resonance imaging during working memory performance in persons with multiple sclerosis

Short Title:
Differential cerebellar activation on functional magnetic resonance imaging during working memory performance in persons with multiple sclerosis
Model System:
TBI
Reference Type:
Journal Article
Accession No.:
J47513.
Journal:
Archives of Physical Medicine and Rehabilitation
Year, Volume, Issue, Page(s):
2004, vol. 85, issue 4, pp 635-639
Publication Website:
Abstract:
Functional magnetic resonance imaging was used to examine cerebellar activation during a working memory task in 8 individuals with multiple sclerosis (MS) and 5 healthy control subjects. Both the control and MS groups showed significantly greater activation in the right cerebellar hemisphere compared with the left side. However, subjects with MS showed no detectable activation in 4 cerebellar substructures that were quite active in healthy subjects: right vermis, right dentate nucleus, right tonsil, and cerebellar peduncle. Findings suggest that the cerebellum may play a role in the working memory impairment observe in MS. Describes study conducted to determine if the finger flexor mapping technique is useful in determining the optimal location for injecting botulinum toxin A within the flexor digitorum superficialis muscle to reduce finger flexor spasticity in patients with acquired brain injury. Modified Ashworth Scale (MAS) ratings were recorded before and after injection to measure spasticity. Results showed significant improvement in mean MAS finger flexor scores indicating that placement of the toxin was effective. The mapping technique appears to be feasible and effective for treating finger flexor spasticity. Further studies are warranted to compare this method of administration with other injection approaches.
Author(s):
Li, Yali; Chiaravalloti, Nancy D.; Hillary, Frank G.; DeLuca, John; Liu, Wen-Ching; Kalnin, Andrew J.; Ricker, Joseph H.; Munin, Michael C.; Navalgund, Brinda K.; Levitt, Donna A.; Breisinger, Terry P.; Zafonte, Ross D.
Author Address(es):

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