Use of the neuropsychiatric inventory in traumatic brain injury: A pilot investigation

Short Title:
Use of the neuropsychiatric inventory in traumatic brain injury: A pilot investigation
Model System:
Reference Type:
Journal Article
Accession No.:
Rehabilitation Psychology
Year, Volume, Issue, Page(s):
2006, vol. 51, issue 3, pp 232-238
Publication Website:
Study assessed the validity of the Neuropsychiatric Inventory (NPI), which was developed to assess psychopathology in dementia, among individuals with traumatic brain injury (TBI). The NPI uses a screen-metric approach to evaluate neuropsychiatric disturbances across 12 domains: delusion, hallucinations, agitation/aggression, dysphoria/depression, anxiety, apathy, irritability/lability, euphoria, disinhibition, aberrant motor behavior, nighttime behavior disturbances, and appetite/eating abnormalities. The screening questions about the presence of difficulties in each specific area are followed by 7 to 9 subquestions (metric items) addressing symptom details if the answer to the screen is affirmative. Using the NPI, caregivers rated the neurobehavioral disturbances of 51 subjects with TBI 1 or 2 years after injury. Caregivers who endorsed the domain screening item also endorsed significantly more metric items within that domain, as would be expected if the screening item accurately measured the psychopathology under consideration. The screen-metric approach yielded an extremely low rate of false positives, although elevated false-positive were obtained on 5 of the 12 domains. Caregivers reported the highest symptom levels for participants on irritability/lability, apathy, and agitation/aggression domains, and rated greater levels of distress associated with those domains and to dysphoria. Overall, the findings provided preliminary support for the accuracy of the NPI in people with TBI.
Kilmer, R. P.; Demakis, G. J.; Hammond, F. M.; Cook, J.; Grattan, K. E.; Kornev, A. A.
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