Bone loss at the knee in spinal cord injury

Short Title:
Bone loss at the knee in spinal cord injury
Model System:
Reference Type:
Journal Article
Accession No.:
Topics in Spinal Cord Injury Rehabilitation
Year, Volume, Issue, Page(s):
2001, vol. 6, issue 3, pp 37-46.
Publication Website:
Set of studies examining the hypothesis that the knee is the most prevalent site of osteoporosis in persons with spinal cord injury (SCI). In one study, the total bone mineral (TBM) of various regions of the body (legs, arms, pelvis, head, and trunk) was measured in men with complete acute SCI (quadriplegia and paraplegia), complete SCI of 16 months duration, and complete SCI of 10 years duration. A second, longitudinal study looked at bone mineral density (BMD) in the tibia and femur in men with acute complete SCI, 14, 30, 60, and 90 days after injury. A third study looked at BMD of the knees in women with complete SCI of at least 18 months duration. A fourth study examined BMD of the knees in 5 men and 5 women with incomplete SCI. A fifth study compared BMD in men with SCI without and without a history of fracture. Results indicate that the majority of bone mineral loss in persons with SCI occurs in the lower extremity, with some loss also occurring at the hip.
Garland, D. E.; Adkins, R. H.
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