Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury

Short Title:
Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury
Model System:
SCI
Reference Type:
Journal Article
Accession No.:
J48657.
Journal:
Archives of Physical Medicine and Rehabilitation
Year, Volume, Issue, Page(s):
2005, vol. 86, issue 2, pp 312-317
Publication Website:
Abstract:
Study examined the relationship between serologic markers and clinical characteristics of people with chronic spinal cord injury (SCI). Serum levels of C-reactive protein (CRP), tumor necrosis factor-alpha, and interleukin-6 were obtained from 37 men with chronic spinal cord injury (SCI) and 10 healthy control subjects. Analysis revealed that asymptomatic people with chronic SCI, especially those with indwelling catheters and pressure ulcers, showed serologic evidence of a systemic inflammatory state. Elevated CRP levels in the SCI group were associated with other clinical signs of chronic disease. Compared with the control group, there was no evidence of chronic elevation in serum levels of the cytokines tumor necrosis factor-alpha and interleukin-6.
Author(s):
Frost, Frederick; Roach, Mary Jo; Kushner, Irving; Schreiber, Peter
Author Address(es):

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