Efficacy of amitriptyline for relief of pain in spinal cord injury: Results of a randomized controlled trial

Short Title:
Efficacy of amitriptyline for relief of pain in spinal cord injury: Results of a randomized controlled trial
Model System:
SCI
Reference Type:
Journal Article
Accession No.:
J50732.
Journal:
Pain
Year, Volume, Issue, Page(s):
2002, vol. 96, issue 3, pp 365-373
Publication Website:
Abstract:
Study assessed whether amitriptyline, a tricyclic antidepressant, is effective in relieving chronic pain and improving pain-related physical and psychosocial dysfunction in people with spinal cord injury (SCI). Eighty-four participants with SCI and chronic pain were randomized to a 6-week trial of amitriptyline or an active placebo, benztropine mesylate. All pre- and post-treatment assessments were conducted by evaluators blind to the allocation. Regression analyses were conducted to examine whether there was a medication group effect on the primary (average pain intensity) and secondary outcome measures. No significant differences were found between the groups in pain intensity or pain-related disability post-treatment, in either intent-to-treat analyses or analyses of study completers. These findings do not support the use of amitriptyline in the treatment of chronic pain in this population.
Author(s):
Cardenas, Diana D.; Warms, Catherine A.; Turner, Judith A.; Marshall, Helen; Brooke, Marvin M.; Loeser, John D.
Author Address(es):

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