Long-term survival after traumatic brain injury: A population-based analysis

Short Title:
Long-term survival after traumatic brain injury: A population-based analysis
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Reference Type:
Journal Article
Accession No.:
Year, Volume, Issue, Page(s):
2004, vol. 19, issue 1, pp 37-43
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Article presents an analysis of long-term survival among a random sample of Americans who experienced traumatic brain injury (TBI). Both 30-day and long-term survival were analyzed for moderate-to-severe and mild TBI cases separately. Review of medical records identified 1,448 confirmed incident cases; 164 were moderate to severe and 1,284 were mild. The estimated 30-day case fatality rate was 29 percent for moderate-to-severe cases and 0.2 percent for mild cases. Comparison of observed mortality with expected mortality revealed a risk ration of 5.29 for moderate-to-severe cases and 1.33 for mild cases. Proportional hazards modeling showed the adjusted hazard of all-cause mortality for moderate-to-severe cases relative to mild cases was 5.18 within 6 months of the event and 1.04 for the remaining follow-up period. Findings indicate that people with mild TBI exhibit a small but statistically significant reduction in long-term survival compared to the general population. The case fatality rate for people with moderate-to-severe TBI is very high, but among 6-month survivors, long-term survival is similar to that for people with mild TBI.
Brown, Allen W.; Leibson, Cynthia L.; Malec, James F.; Perkins, Patricia K.; Diehl, Nancy N.; Larson, Dirk R.
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