Double-Blind, Placebo-controlled Trial of Amantadine Hydrochloride in the Treatment of Chronic TBI Irritability and Aggression: A Replication Study

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Irritability is reported by both individuals with TBI and their families as the most common of the permanent post-TBI personality and behavioral issues. Irritability can be highly disruptive socially and at work, a major family burden, and an interference to receiving appropriate care. In severe cases, behaviors may be so disruptive that one cannot live at home. We hope to show that Amantadine Hydrochloride can be effective in reducing this type of post-TBI irritability.