Identification of the Pathways to Scarring

Project Type
Principal Investigator Name
Loren H. Engrav, MD
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Target Population(s):
burn survivors with scarring
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The broad long-term objective is to understand the cause of hypertrophic scarring after burns, with the intent of eliminating this devastating outcome and thereby improving rehabilitation after burn injury. The specific aim is to translate the porcine gene data to the human equivalent and then identify the gene pathways of human fibroproliferative scarring. We hypothesize that the Duroc/Yorkshire shallow/deep wound gene expression data can be translated into the human equivalent and will reveal the gene pathways to human fibroproliferative scarring.