Prevalence of Vitamin D Deficiency in Acute and Chronic Spinal Cord Injury
Principal Investigator Name
Gregory Nemunaitis, M.D.
Principal Investigator Email
SCI Patients Admitted to Acute Rehab
Objective: To assess the prevalence of vitamin D deficiency in patients with acute and chronic spinal cord injury (SCI) admitted to an inpatient rehabilitation service and identify injury related characteristics that predict variations in serum Vitamin D, 25-OH (VitD-25(OH)) level.
Design: Retrospective case series
Setting: Academic inpatient SCI rehabilitation program
Participants/Methods: One hundred consecutive patients with SCI admitted to inpatient rehabilitation. Data was abstracted from patientsâ€™ medical chart. Frequencies, means and standard deviations, Pearson Correlation, and Linear Regression were used to analyze the data.
Intervention: Not applicable
Main Outcome Measure: VitD-25(OH) level
Results: 94/100 SCI patients admitted between January 2007 and December 2007 had VitD- 25(OH) concentrations below the optimal value of 30ng/mL. The mean VitD-25(OH) level was 16.29 Â± 7.73 ng/mL with a range from 7.00 to 36.80 ng/ml. Blacks had statistically significant lower mean VitD-25(OH) levels compared to Whites (12.96 vs. 17.79 ng/mL, p =.001). Three stage linear regression identified race as the only factor to have a statistically significant relationship with VitD-25(OH) concentration (b= -4.800, p = .005).
Conclusions: The prevalence of VitD-25(OH) deficiency was 94% in this sample of patients with SCI. Blacks had lower VitD-25(OH) concentrations compared to Whites. Age, gender, etiology, level and completeness of lesion, winter season and number of days since injury were not associated with VitD-25(OH) levels. Surveillance of VitD-25(OH) should be part of routine health exams for persons with SCI as this study shows all persons with SCI had below optimal VitD-25 (OH) levels, which may be contributing to the high incidence of osteoporosis in this group.